Marshall syndrome is a rare genetic disorder that falls under the category of periodic fever syndromes. It is also known as PFAPA syndrome, which stands for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. This condition typically affects children and is characterized by recurrent episodes of fever, sore throat, mouth ulcers, and swollen lymph nodes in the neck.
The exact cause of Marshall syndrome is not yet fully understood, but it is believed to have a genetic component. The episodes of fever and other symptoms tend to occur at regular intervals, usually every few weeks, and can last for a few days to a week. Between episodes, affected individuals are generally healthy.
Diagnosis of Marshall syndrome is based on the presence of characteristic symptoms and ruling out other possible causes. Treatment often involves managing the symptoms with nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce fever and pain. In some cases, tonsillectomy may be recommended to alleviate symptoms and prevent future episodes.
While Marshall syndrome can significantly impact the quality of life during episodes, it is generally not associated with long-term complications or serious health risks. With appropriate management and support, individuals with Marshall syndrome can lead normal and fulfilling lives.