What is May Hegglin Anomaly

May-Hegglin Anomaly (MHA) is a rare genetic disorder that affects the blood and platelets. It is characterized by the presence of large platelets, abnormal white blood cells called Döhle-like bodies, and a low platelet count (thrombocytopenia). MHA is inherited in an autosomal dominant pattern, meaning that a person only needs to inherit one copy of the mutated gene from either parent to develop the condition.

The main features of May-Hegglin Anomaly include:

• Large platelets: Individuals with MHA have larger than normal platelets, which can impair their ability to form blood clots properly.


• Döhle-like bodies: These are abnormal structures found in the white blood cells of individuals with MHA. They appear as pale blue inclusions under a microscope.


• Thrombocytopenia: MHA causes a low platelet count, which can lead to easy bruising, nosebleeds, and prolonged bleeding.

While most individuals with May-Hegglin Anomaly lead normal lives without significant health issues, some may experience bleeding complications or require medical intervention in certain situations. Treatment options may include platelet transfusions or medications to manage bleeding symptoms.