What is the prevalence of Mal de Meleda?
How many people does Mal de Meleda affect? Does it have the same prevalence in men and women? And in the different countries?
Mal de Meleda is a rare autosomal recessive genetic disorder characterized by thickening of the skin on the palms and soles. It is most commonly found in individuals of Mediterranean descent, particularly in the island of Meleda in Croatia. The prevalence of Mal de Meleda is estimated to be around 1 in 100,000 to 1 in 200,000 individuals worldwide. Due to its rarity, it is considered a very uncommon condition. Early diagnosis and management are crucial for individuals affected by this disorder.
Mal de Meleda is a rare genetic disorder characterized by thickening of the skin on the palms of the hands and soles of the feet. It is inherited in an autosomal recessive manner, meaning that both parents must carry a copy of the mutated gene for their child to be affected.
The prevalence of Mal de Meleda is extremely low, with only a few hundred cases reported worldwide. It is most commonly found in individuals of Mediterranean descent, particularly in the island of Meleda in Croatia, from which the disorder gets its name.
Due to its rarity, the exact prevalence of Mal de Meleda is difficult to determine. However, it is estimated to affect approximately 1 in every 100,000 to 200,000 individuals globally. The disorder typically presents in early childhood and persists throughout life, causing significant physical and functional impairment.
Although there is currently no cure for Mal de Meleda, treatment focuses on managing symptoms and preventing complications. This may include regular moisturizing, keratolytic agents, and physical therapy to improve hand function.
