Mal de Meleda is a rare genetic disorder characterized by thickening of the skin on the palms of the hands and soles of the feet. This condition is also known as Meleda disease or keratosis palmoplantaris transgrediens.
Individuals with Mal de Meleda experience excessive skin growth, leading to the formation of thick, dry, and scaly patches on the affected areas. The condition typically begins in infancy or early childhood and progresses slowly over time. In some cases, the skin abnormalities may extend beyond the palms and soles, affecting other parts of the body such as the elbows, knees, and trunk.
Although the exact cause of Mal de Meleda is not fully understood, it is known to be an autosomal recessive disorder, meaning that both parents must carry a mutated gene for their child to be affected. The condition is caused by mutations in the SLURP1 gene, which plays a role in regulating the growth and development of the skin.
There is currently no cure for Mal de Meleda, and treatment focuses on managing the symptoms and preventing complications. Moisturizers and keratolytic agents may be used to soften the thickened skin and reduce scaling. Regular exfoliation and the use of emollients can help maintain skin hydration. In severe cases, surgical procedures such as skin grafting or laser therapy may be considered to improve mobility and function.
It is important for individuals with Mal de Meleda to receive ongoing medical care and support. Dermatologists and genetic counselors can provide guidance on managing the condition and offer genetic testing and counseling for affected individuals and their families.