Mikulicz Syndrome synonyms

Mikulicz Syndrome is a rare autoimmune disorder characterized by the chronic inflammation of the salivary and lacrimal glands, resulting in their enlargement and dysfunction. This condition was first described by the Austrian surgeon Johann von Mikulicz-Radecki in the late 19th century. Although it was initially thought to be a distinct disease, it is now considered a manifestation of various underlying conditions, such as Sjögren's syndrome, sarcoidosis, lymphoma, or IgG4-related disease.

Due to its association with different underlying causes, Mikulicz Syndrome is also known by several synonyms, including:

• IgG4-related dacryoadenitis and sialadenitis: This term is used when the syndrome is associated with IgG4-related disease, a chronic fibroinflammatory condition that can affect multiple organs.


• Secondary Sjögren's syndrome: When Mikulicz Syndrome occurs as a result of Sjögren's syndrome, an autoimmune disorder primarily affecting the salivary and lacrimal glands, it is referred to as secondary Sjögren's syndrome.


• Benign lymphoepithelial lesion: This term is used when the enlargement of the salivary and lacrimal glands is caused by lymphoma, a type of cancer that affects the lymphatic system.


• Chronic dacryoadenitis: When the inflammation primarily affects the lacrimal glands, it is referred to as chronic dacryoadenitis.

It is important to note that Mikulicz Syndrome is a clinical diagnosis, and further investigations are necessary to determine the underlying cause. These may include blood tests, imaging studies, and sometimes biopsies. Treatment depends on the specific underlying condition and may involve medications to suppress the immune system, manage symptoms, or address any associated complications.