Monosomy 6p25 is a rare genetic disorder characterized by the deletion of a portion of the short arm of chromosome 6. This condition affects various aspects of development and can lead to a range of physical and intellectual disabilities. Individuals with monosomy 6p25 may exhibit distinctive facial features, such as a prominent forehead, a broad nasal bridge, and a small chin. They may also experience delays in reaching developmental milestones, intellectual disabilities, and speech and language difficulties. Additionally, some individuals may have heart defects, skeletal abnormalities, or kidney problems. The severity of symptoms can vary widely among affected individuals. Genetic testing is typically used to diagnose monosomy 6p25, and management involves addressing the specific symptoms and providing supportive care. Ongoing medical monitoring and early intervention services can help optimize the quality of life for individuals with this condition.