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What is the history of Myasthenia Gravis?

When was Myasthenia Gravis discovered? What is the story of this discovery? Was it coincidence or not?

History of Myasthenia Gravis

Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder that affects the voluntary muscles of the body. The history of MG dates back to the late 19th century when it was first recognized and described by several physicians.



In 1877, German physician Wilhelm Heinrich Erb observed a patient with muscle weakness and fatigue that worsened with exertion. He named this condition "myasthenia gravis," which translates to "grave muscle weakness" in Latin.



In 1895, British neurologist Sir William Richard Gowers provided further insights into the disorder. He described the characteristic fluctuating muscle weakness and noted that the condition primarily affected the muscles controlled by the cranial nerves.



In the early 20th century, advancements in medical research led to a better understanding of the underlying mechanisms of MG. In 1930, Mary Walker, an American neurologist, discovered that the weakness in MG was due to a defect in neuromuscular transmission.



In 1934, British physiologist Henry Hallett Dale and his colleagues identified acetylcholine as the neurotransmitter responsible for transmitting signals between nerves and muscles. This finding was crucial in understanding the pathophysiology of MG.



In the 1950s, significant progress was made in the treatment of MG. American neurologist Osserman and English physician Dr. John Newsom-Davis independently classified MG into different subtypes based on the severity and distribution of muscle weakness.



In 1957, American neurologist Dr. Mary Broadfoot Walker introduced the use of anticholinesterase drugs, such as pyridostigmine, to improve muscle strength in MG patients. These medications became a cornerstone of MG treatment and are still widely used today.



In the 1970s, the discovery of autoantibodies against the acetylcholine receptor (AChR) provided further insights into the autoimmune nature of MG. This breakthrough allowed for more accurate diagnosis and monitoring of the disease.



In the late 20th century, advancements in immunology and molecular biology led to the identification of additional autoantibodies associated with MG. These include antibodies against muscle-specific kinase (MuSK) and low-density lipoprotein receptor-related protein 4 (LRP4).



In recent years, research has focused on developing new treatment options for MG. Therapies such as immunosuppressive drugs, intravenous immunoglobulin (IVIG), plasma exchange, and monoclonal antibodies targeting specific immune cells have shown promising results in managing the disease.



Today, with ongoing research and advancements in medical science, the understanding and management of Myasthenia Gravis continue to evolve. While there is no cure for MG, early diagnosis and appropriate treatment can significantly improve the quality of life for individuals living with this chronic condition.


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