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Which are the causes of Myelofibrosis?

See some of the causes of Myelofibrosis according to people who have experience in Myelofibrosis

Myelofibrosis causes

Myelofibrosis is a rare and chronic bone marrow disorder characterized by the abnormal production of blood cells and the development of fibrous scar tissue in the bone marrow. This condition belongs to a group of diseases known as myeloproliferative neoplasms (MPNs), which involve the overproduction of certain blood cells.



The exact cause of myelofibrosis is not fully understood, but several factors have been identified as potential contributors to its development:



1. Genetic Mutations:


Genetic mutations play a significant role in the development of myelofibrosis. The most common mutation associated with this condition is called Janus kinase 2 (JAK2) mutation. This mutation leads to the overactivation of the JAK-STAT signaling pathway, which controls the production of blood cells. Other mutations, such as CALR and MPL, have also been linked to myelofibrosis.



2. Age:


Myelofibrosis is more commonly diagnosed in individuals over the age of 50, although it can occur at any age. The risk of developing myelofibrosis increases with age, and the disease tends to progress more rapidly in older individuals.



3. Previous MPN:


Some individuals with a history of other myeloproliferative neoplasms, such as polycythemia vera or essential thrombocythemia, may develop myelofibrosis. This progression from one MPN to another is known as secondary myelofibrosis.



4. Environmental Factors:


Exposure to certain environmental factors may contribute to the development of myelofibrosis, although the specific triggers are not well-defined. Some studies suggest a potential link between myelofibrosis and exposure to certain chemicals, such as benzene or toluene, which are found in some industrial settings.



5. Inherited Predisposition:


While myelofibrosis is not typically inherited, there may be a genetic predisposition to developing MPNs. Certain inherited gene mutations, such as those associated with familial thrombocytosis, have been identified in some individuals with myelofibrosis.



6. Unknown Factors:


Despite extensive research, there are still unknown factors that contribute to the development of myelofibrosis. Further studies are needed to uncover these factors and gain a deeper understanding of the disease.



It is important to note that myelofibrosis is a complex condition, and the interplay of various factors likely contributes to its onset and progression. While the causes mentioned above have been associated with myelofibrosis, it is essential to consult with a healthcare professional for a comprehensive evaluation and accurate diagnosis.


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I was recently told I have myelofbrosis (6-28-16) and so far I'm flying blind. I don't know what stage I'm at, nor do I know how longI've had this, but I have an appt. with my onocoligist on 7-14-16 and that is going to be one of my first questions. ...

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