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Which are the causes of Omphalocele?

See some of the causes of Omphalocele according to people who have experience in Omphalocele

Omphalocele causes

Omphalocele is a congenital birth defect characterized by the presence of an abdominal wall defect at the umbilical region, resulting in the protrusion of abdominal organs outside the body. This condition occurs during fetal development when the muscles in the abdominal wall fail to close properly around the umbilical cord. The exact cause of omphalocele is not fully understood, but several factors have been identified as potential contributors.



Genetic Factors: Studies have shown that omphalocele can be associated with certain genetic abnormalities. Chromosomal abnormalities, such as trisomy 13, trisomy 18, and trisomy 21 (Down syndrome), have been found to increase the risk of omphalocele. Additionally, certain genetic syndromes, such as Beckwith-Wiedemann syndrome and Pentalogy of Cantrell, have been linked to the development of omphalocele.



Environmental Factors: Exposure to certain environmental factors during pregnancy has been suggested as a possible cause of omphalocele. Maternal smoking, alcohol consumption, and illicit drug use have been associated with an increased risk of this condition. Additionally, maternal obesity and uncontrolled diabetes may also contribute to the development of omphalocele.



Maternal Age: Advanced maternal age has been identified as a risk factor for omphalocele. Women who become pregnant at an older age, typically above 35 years, have a higher likelihood of having a baby with omphalocele compared to younger mothers.



Other Birth Defects: Omphalocele can sometimes occur in conjunction with other birth defects. This suggests that there may be shared underlying causes or genetic factors contributing to multiple congenital anomalies. It is important to thoroughly evaluate and monitor infants with omphalocele for the presence of other associated abnormalities.



Family History: There is evidence to suggest that omphalocele may have a familial component. If a parent or a sibling has been diagnosed with omphalocele, the risk of having a baby with the condition may be increased.



It is important to note that in many cases, the exact cause of omphalocele remains unknown. The condition is likely multifactorial, involving a combination of genetic and environmental factors. Further research is needed to fully understand the complex mechanisms underlying the development of omphalocele.


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