Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and potentially life-threatening blood disorder characterized by the destruction of red blood cells. It is also known by several other names, which are used interchangeably to describe the same condition.
One of the most commonly used synonyms for PNH is Marchiafava-Micheli Syndrome. This name is derived from the Italian physicians who first described the disorder in the late 19th century. Another synonym is Ham's Syndrome, named after the scientist who developed a diagnostic test for PNH called the Ham's test.
PNH is also referred to as Nocturnal Paroxysmal Hemoglobinuria, emphasizing the characteristic paroxysmal nature of the symptoms, which often occur during sleep. Additionally, it is sometimes called PNH Disease or simply PNH for short.
Furthermore, PNH is occasionally referred to as Acquired Hemolytic Anemia, highlighting the fact that it is an acquired disorder rather than one that is inherited. Another synonym is Intravascular Hemolysis, which describes the process of red blood cell destruction that occurs within the blood vessels.
It is important to note that while these terms are used interchangeably, they all refer to the same underlying condition – Paroxysmal Nocturnal Hemoglobinuria.