Pityriasis lichenoides et varioliformis acuta (PLEVA) is a rare skin disorder characterized by the development of small, red, scaly papules that may progress to form vesicles or pustules. The exact cause of PLEVA is unknown, but it is believed to be an abnormal immune response to various triggers, such as infections or medications.
Diagnosing PLEVA can be challenging as it shares similarities with other skin conditions. A thorough medical history and physical examination are crucial in the diagnostic process. The dermatologist will carefully examine the skin lesions, noting their appearance, distribution, and any associated symptoms.
Biopsy is often performed to confirm the diagnosis. During a biopsy, a small sample of the affected skin is taken and examined under a microscope. This allows the dermatopathologist to observe the characteristic features of PLEVA, such as a dense infiltrate of inflammatory cells and the presence of necrotic keratinocytes.
In some cases, additional tests may be conducted to rule out other conditions or identify potential triggers. These tests may include:
It is important to note that PLEVA is a diagnosis of exclusion, meaning other conditions with similar symptoms must be ruled out before confirming PLEVA. The dermatologist will consider the clinical presentation, biopsy results, and test findings to make an accurate diagnosis.
Once diagnosed, appropriate treatment options can be discussed with the patient. These may include topical corticosteroids, phototherapy, antibiotics (if an infection is present), or systemic medications to suppress the immune response. Regular follow-up appointments are typically scheduled to monitor the condition's progress and adjust the treatment plan if necessary.