Which are the symptoms of Primary Sclerosing Cholangitis?

Symptoms of Primary Sclerosing Cholangitis

Primary Sclerosing Cholangitis (PSC) is a chronic liver disease characterized by inflammation and scarring of the bile ducts inside and outside the liver. It primarily affects middle-aged individuals and is more common in men than women. PSC is a progressive condition that can lead to liver damage, cirrhosis, and eventually liver failure. While the exact cause of PSC is unknown, it is believed to involve an autoimmune response.

The symptoms of Primary Sclerosing Cholangitis can vary from person to person, and some individuals may not experience any symptoms at all in the early stages. However, as the disease progresses, the following signs and symptoms may become more apparent:

1. Fatigue

Fatigue is a common symptom experienced by individuals with PSC. It can be persistent and debilitating, affecting daily activities and quality of life.

2. Itching

Itching (pruritus) is another common symptom of PSC. It is often severe and can be difficult to manage. The itching is believed to be caused by the buildup of bile acids in the bloodstream due to impaired bile flow.

3. Jaundice

Jaundice is characterized by yellowing of the skin and eyes. It occurs when there is a buildup of bilirubin, a yellow pigment produced during the breakdown of red blood cells, in the body. In PSC, jaundice may develop as the disease progresses and liver function becomes impaired.

4. Abdominal pain

Abdominal pain is a common symptom in individuals with PSC. It can range from mild discomfort to severe pain and is often located in the upper right quadrant of the abdomen. The pain may be intermittent or constant.

5. Weight loss

Unintentional weight loss is a common symptom of PSC. It can occur due to a combination of factors, including decreased appetite, malabsorption of nutrients, and increased metabolic demands caused by the underlying liver disease.

6. Fever and chills

Fever and chills may occur in some individuals with PSC, particularly during episodes of cholangitis. Cholangitis is an infection of the bile ducts that can occur as a complication of PSC.

7. Enlarged liver or spleen

In advanced stages of PSC, the liver or spleen may become enlarged. This can be detected during a physical examination by a healthcare professional.

It is important to note that these symptoms can also be associated with other liver and biliary conditions. Therefore, a proper diagnosis by a healthcare professional is crucial for determining the underlying cause and initiating appropriate treatment.

If you are experiencing any of these symptoms or have concerns about your liver health, it is recommended to seek medical attention for a thorough evaluation and diagnosis.