Progressive Osseous Heteroplasia (POH) is a rare genetic disorder characterized by the formation of bone in soft tissues such as muscles and skin. It is not contagious and cannot be transmitted from person to person. POH is caused by a mutation in the GNAS gene and is typically inherited in an autosomal dominant pattern. The condition leads to progressive bone formation, which can cause limitations in mobility and other complications. Proper medical management and support are crucial for individuals with POH.
Progressive Osseous Heteroplasia (POH) is a rare genetic disorder characterized by the abnormal formation of bone in soft tissues such as muscles, tendons, and ligaments. It is caused by a mutation in the GNAS gene, which leads to the production of an abnormal protein. POH is not contagious and cannot be transmitted from one person to another.
POH is an autosomal dominant disorder, meaning that a person only needs to inherit one copy of the mutated gene from either parent to develop the condition. However, most cases of POH occur sporadically, meaning they are not inherited from a parent.
The symptoms of POH typically appear in childhood and progress over time. They may include the formation of bone in the skin, restricted joint movement, and skeletal abnormalities. The severity and progression of the disease can vary widely among individuals.
As of now, there is no cure for POH. Treatment mainly focuses on managing symptoms and preventing complications. This may involve physical therapy, medications to relieve pain and inflammation, and surgical interventions to address severe skeletal abnormalities.
It is important to note that POH is not contagious and does not pose a risk of transmission to others. It is a genetic disorder that is present from birth and cannot be acquired through contact or exposure to an affected individual.