Which are the causes of Psoriasis?

Causes of Psoriasis

Psoriasis is a chronic autoimmune skin condition that affects millions of people worldwide. While the exact cause of psoriasis is still not fully understood, researchers believe that a combination of genetic, immune system, and environmental factors contribute to its development. Let's explore these causes in more detail:

Genetic Factors

Family history plays a significant role in the development of psoriasis. Studies have shown that certain genes are associated with an increased risk of developing the condition. The most notable gene is called HLA-Cw6, which is found in a significant number of individuals with psoriasis. However, having these genes does not guarantee that a person will develop psoriasis, as other factors also come into play.

Immune System Dysfunction

Psoriasis is considered an autoimmune disease, which means the immune system mistakenly attacks healthy cells in the body. In psoriasis, immune cells called T cells become overactive and trigger inflammation. This inflammation leads to the rapid turnover of skin cells, resulting in the characteristic symptoms of psoriasis, such as red, scaly patches.

It is still unclear why the immune system malfunctions in individuals with psoriasis. However, it is believed that a combination of genetic and environmental factors contribute to this immune system dysfunction.

Environmental Triggers

Various environmental factors can trigger or exacerbate psoriasis symptoms in susceptible individuals. These triggers can vary from person to person, but some common ones include:

• Stress: Emotional stress can worsen psoriasis symptoms or trigger flare-ups.


• Infections: Certain infections, particularly streptococcal infections, can cause or aggravate psoriasis.


• Injury to the Skin: Skin trauma, such as cuts, burns, or bug bites, can trigger psoriasis symptoms in some individuals. This phenomenon is known as the Koebner response.


• Medications: Certain medications, such as lithium, antimalarials, and beta-blockers, have been associated with psoriasis development or worsening of symptoms.


• Smoking and Alcohol: Both smoking and excessive alcohol consumption have been linked to an increased risk of developing psoriasis and worsening of symptoms.

Other Factors

While less understood, several other factors may contribute to the development of psoriasis:

• Hormonal Changes: Fluctuations in hormone levels, such as during puberty or menopause, may influence psoriasis development.


• Obesity: Obesity is associated with an increased risk of psoriasis and can make existing symptoms more severe.


• Weather Conditions: Cold, dry weather can worsen psoriasis symptoms, while warm, sunny climates may improve them.

It is important to note that psoriasis is a complex condition, and the interplay between these factors can vary from person to person. While we have made significant progress in understanding the causes of psoriasis, further research is still needed to unravel the complete picture.