What is the prevalence of Sacral agenesis / Caudal regression syndrome?
How many people does Sacral agenesis / Caudal regression syndrome affect? Does it have the same prevalence in men and women? And in the different countries?
Sacral agenesis / Caudal regression syndrome is a rare congenital disorder characterized by the incomplete development of the lower spine and spinal cord. It affects approximately 1 in every 25,000 to 40,000 live births worldwide. The prevalence may vary across different populations and ethnicities. This condition can lead to various physical abnormalities, including malformation or absence of the sacrum, lower limb paralysis, and bowel and bladder dysfunction. The severity of symptoms can vary widely, ranging from mild to severe. Early diagnosis and appropriate medical management are crucial for optimizing outcomes and improving quality of life for individuals with this syndrome.
Sacral agenesis, also known as Caudal Regression Syndrome (CRS), is a rare congenital disorder that affects the development of the lower spine and spinal cord. It is characterized by the absence or underdevelopment of the sacrum, the triangular bone at the base of the spine, and sometimes extends to the lumbar and thoracic vertebrae.
The prevalence of Sacral agenesis/CRS is estimated to be around 1 in every 25,000 to 50,000 live births. However, the exact prevalence may vary across different populations and regions. This condition is more commonly observed in individuals of Hispanic descent and has a slightly higher incidence in females compared to males.
Sacral agenesis/CRS can lead to various physical and neurological impairments, including lower limb abnormalities, bladder and bowel dysfunction, and spinal cord abnormalities. The severity of symptoms can range from mild to severe, depending on the extent of the malformation.
Early diagnosis and appropriate medical interventions, such as physical therapy, orthopedic interventions, and urological management, can help improve the quality of life for individuals with Sacral agenesis/CRS. However, it is important to note that the prognosis and outcomes can vary widely depending on the individual and the specific characteristics of their condition.
