What is Sneddon Syndrome

Sneddon Syndrome is a rare and chronic disorder that affects the blood vessels in the skin and brain. It is characterized by the combination of livedo reticularis, a mottled purplish discoloration of the skin, and cerebrovascular events such as strokes or transient ischemic attacks (TIAs).

Livedo reticularis refers to the net-like pattern of discoloration on the skin, typically seen on the legs, arms, or trunk. This occurs due to the narrowing of blood vessels, leading to reduced blood flow.

The cerebrovascular events associated with Sneddon Syndrome can cause a range of neurological symptoms, including headaches, cognitive impairment, seizures, and in severe cases, strokes. These events occur due to the blockage or inflammation of blood vessels in the brain.

The exact cause of Sneddon Syndrome is unknown, but it is believed to involve an autoimmune response, where the body's immune system mistakenly attacks its own blood vessels. It primarily affects women in their 30s to 50s.

Diagnosis of Sneddon Syndrome involves a thorough medical history, physical examination, and various imaging tests to assess blood flow and detect any brain abnormalities. Treatment focuses on managing symptoms and preventing further cerebrovascular events through medications such as antiplatelet agents and immunosuppressants.