TNF Receptor Associated Periodic Syndrome (TRAPS) is a rare genetic autoinflammatory disorder that was first described in 1982 by Dr. Michael McDermott. It is also known as Familial Hibernian Fever or Hibernian Fever. TRAPS is characterized by recurrent episodes of fever, abdominal pain, rash, joint pain, and muscle pain.
The history of TRAPS begins with the identification of the tumor necrosis factor (TNF) receptor 1 gene (TNFRSF1A) in 1991. This gene encodes the protein responsible for binding TNF, a cytokine involved in the regulation of inflammation. Mutations in the TNFRSF1A gene were later found to be associated with TRAPS.
In 1999, the first comprehensive clinical description of TRAPS was published by McDermott and colleagues. They reported on a large Irish-American family with a history of recurrent fevers and other symptoms. This study provided valuable insights into the clinical manifestations and inheritance pattern of TRAPS.
Further research in the early 2000s led to the discovery of additional TNFRSF1A mutations in individuals with TRAPS. These mutations were found to affect the function of the TNF receptor, leading to dysregulated inflammation and the characteristic symptoms of the syndrome.
As more cases of TRAPS were identified, it became clear that the disorder is not limited to individuals of Irish descent. TRAPS has been reported in various ethnic groups worldwide, indicating its global prevalence.
Over the years, the understanding of TRAPS has deepened through clinical observations and molecular studies. The identification of specific TNFRSF1A mutations associated with TRAPS has allowed for genetic testing and diagnosis of the syndrome. This has been particularly important in cases where the clinical presentation is atypical or overlaps with other autoinflammatory disorders.
Management of TRAPS typically involves the use of anti-inflammatory medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, to control symptoms during acute episodes. In some cases, biologic agents targeting TNF, such as etanercept, have been used to reduce inflammation and prevent recurrent episodes.
Despite advances in understanding and treatment, challenges remain in the management of TRAPS. The unpredictable nature of the syndrome and the variability in symptom severity make it difficult to develop standardized treatment guidelines. Additionally, the long-term effects of chronic inflammation in TRAPS are still being studied.
Research efforts continue to unravel the underlying mechanisms of TRAPS and explore potential therapeutic targets. The development of novel biologic agents and targeted therapies holds promise for improving the quality of life for individuals with TRAPS.
In conclusion, TNF Receptor Associated Periodic Syndrome (TRAPS) is a rare autoinflammatory disorder characterized by recurrent episodes of fever, abdominal pain, rash, joint pain, and muscle pain. The identification of TNFRSF1A mutations associated with TRAPS has revolutionized the diagnosis and understanding of the syndrome. Ongoing research aims to improve management strategies and develop targeted therapies for individuals with TRAPS.