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Which are the causes of Truncus Arteriosus?

See some of the causes of Truncus Arteriosus according to people who have experience in Truncus Arteriosus

Truncus Arteriosus causes

Truncus arteriosus is a rare congenital heart defect that occurs during fetal development. It is characterized by a single large blood vessel, known as the truncus arteriosus, arising from the heart instead of the normal two separate vessels (the aorta and pulmonary artery). This condition leads to mixing of oxygenated and deoxygenated blood, resulting in inadequate oxygen supply to the body.



The exact cause of truncus arteriosus is not fully understood, but it is believed to be a combination of genetic and environmental factors. Here are some of the potential causes:



Genetic Factors:


Truncus arteriosus can be associated with certain genetic abnormalities, such as DiGeorge syndrome, which is caused by a deletion of a small piece of chromosome 22. Other genetic conditions, including 22q11.2 deletion syndrome and Down syndrome, have also been linked to an increased risk of developing truncus arteriosus.



Environmental Factors:


Exposure to certain environmental factors during pregnancy may increase the risk of truncus arteriosus. Maternal use of tobacco, alcohol, or certain medications, such as retinoic acid derivatives, has been associated with an elevated risk of congenital heart defects, including truncus arteriosus.



Developmental Factors:


Truncus arteriosus occurs during fetal development when the heart is forming. It is thought to result from a failure of the truncus arteriosus to divide into the aorta and pulmonary artery, leading to the single vessel. The exact reasons for this developmental abnormality are not fully understood, but it may involve disruptions in the signaling pathways and interactions between different cells and tissues during heart development.



Family History:


Having a family history of congenital heart defects, including truncus arteriosus, increases the risk of an individual developing the condition. Certain genetic mutations or variations may be passed down through generations, predisposing individuals to heart abnormalities.



Overall, truncus arteriosus is a complex condition with multiple potential causes. Genetic factors, environmental exposures, developmental abnormalities, and family history all play a role in the development of this congenital heart defect.


Diseasemaps
2 answers
I don't think that truly know what causes Truncus. Maybe it is just a fluke during the time we were developing. My theory is that mine was caused by my dad's exposure to agent orange during the Vietnam War. Who knows if that will ever be proved, but that is my thoughts.

Posted May 21, 2017 by Jennifer 700

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APRIL 27TH 2017 my son jacob was born in mitchell sd. Within hours of his birth he was flown to sioux falls sd after discovering his heart condition. The very next day he was flown to Omaha children's hospital, in route to the hospital his intestines...
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