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What is the prevalence of Undifferentiated Connective Tissue Disease?

How many people does Undifferentiated Connective Tissue Disease affect? Does it have the same prevalence in men and women? And in the different countries?

Prevalence of Undifferentiated Connective Tissue Disease

Undifferentiated Connective Tissue Disease (UCTD) is a condition characterized by symptoms and findings that overlap with various connective tissue diseases, such as lupus, rheumatoid arthritis, and scleroderma. The prevalence of UCTD is challenging to determine precisely due to its heterogeneous nature and varying diagnostic criteria. However, studies suggest that UCTD affects approximately 2-3% of the general population. It is more common in women than men, with a female-to-male ratio of around 10:1. Early recognition and appropriate management are crucial in improving outcomes for individuals with UCTD.



Undifferentiated Connective Tissue Disease (UCTD) is a condition characterized by symptoms and laboratory findings that overlap with various connective tissue diseases, such as lupus, rheumatoid arthritis, and scleroderma. However, it does not meet the specific diagnostic criteria for any particular disease.


The prevalence of UCTD is difficult to determine precisely due to its nature as an undifferentiated condition. Estimates suggest that it affects approximately 1-2% of the general population. However, it is important to note that the prevalence may vary depending on the population studied and the diagnostic criteria used.


UCTD predominantly affects women, with a female-to-male ratio of around 10:1. It can occur at any age, but it is most commonly diagnosed in individuals between 30 and 50 years old.


While UCTD may not be as well-known as other connective tissue diseases, it is still a significant health concern. Early detection and appropriate management are crucial in improving the quality of life for individuals with UCTD.


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I have been telling medical providers about vague pains in shoulders, arms, wrists , fingers and hips for many years. Have also reported dry skin with rashes, intercourse problems due to vaginal dryness and just last year was diagnosed with dry eyes....

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