What is Von Willebrand Disease

Von Willebrand Disease (VWD) is a genetic bleeding disorder that affects the blood's ability to clot properly. It is caused by a deficiency or dysfunction of von Willebrand factor (vWF), a protein that plays a crucial role in blood clotting. vWF helps platelets stick together and adhere to the walls of blood vessels, forming a clot to stop bleeding.

VWD can lead to prolonged bleeding, easy bruising, and excessive bleeding after injuries or surgeries. Symptoms may vary from mild to severe, depending on the level of vWF and the specific subtype of the disease. It is typically inherited in an autosomal dominant pattern, meaning that a person with VWD has a 50% chance of passing it on to their children.

Diagnosis of VWD involves a series of blood tests, including measuring vWF levels, platelet function, and clotting factor activity. Genetic testing may also be conducted to identify specific mutations.

Treatment for VWD aims to prevent or control bleeding episodes. This may involve medications such as desmopressin (DDAVP) to increase vWF levels, clot-stabilizing drugs, or replacement therapy with vWF concentrates or plasma-derived clotting factors.

Individuals with VWD can lead normal lives with proper management and care. It is important for patients to work closely with healthcare professionals to develop a personalized treatment plan and take necessary precautions to minimize the risk of bleeding.