Which are the symptoms of Waldenstrom Macroglobulinemia?

Symptoms of Waldenstrom Macroglobulinemia

Waldenstrom Macroglobulinemia (WM) is a rare type of cancer that affects the bone marrow and causes the overproduction of abnormal white blood cells called lymphoplasmacytic cells. These cells produce an abnormal protein called monoclonal immunoglobulin M (IgM) antibody, which can lead to a variety of symptoms. The symptoms of WM can vary from person to person, and some individuals may not experience any symptoms at all in the early stages of the disease.

General Symptoms

Some general symptoms that may be present in individuals with Waldenstrom Macroglobulinemia include:

• Fatigue: Feeling excessively tired or weak is a common symptom of WM. This fatigue can be persistent and may not improve with rest.


• Weight loss: Unexplained weight loss can occur in individuals with WM.


• Night sweats: Excessive sweating during the night, leading to damp sleepwear and bedding, is a symptom that some individuals with WM may experience.


• Fever: Low-grade fevers that come and go can be a sign of WM.

Bleeding and Bruising

Due to the abnormal production of blood cells in WM, individuals may experience symptoms related to bleeding and bruising, including:

• Nosebleeds: Frequent or prolonged nosebleeds can occur in individuals with WM.


• Easy bruising: The abnormal blood cells in WM can affect the clotting process, leading to easy bruising even with minor injuries.


• Prolonged bleeding: Cuts or wounds may take longer to stop bleeding in individuals with WM.

Enlarged Lymph Nodes and Organs

As WM progresses, it can cause the lymph nodes and other organs to become enlarged. This can result in symptoms such as:

• Enlarged lymph nodes: Lymph nodes in the neck, armpits, groin, or other areas of the body may become swollen and tender.


• Enlarged liver or spleen: The liver or spleen may become enlarged, leading to discomfort or pain in the upper abdomen.

Neurological Symptoms

In some cases, WM can affect the nervous system, leading to neurological symptoms. These may include:

• Headaches: Persistent or severe headaches can occur in individuals with WM.


• Dizziness or lightheadedness: Feeling dizzy or lightheaded may be a symptom of WM.


• Visual disturbances: Blurred vision, double vision, or other visual changes can occur.


• Peripheral neuropathy: Numbness, tingling, or weakness in the hands or feet may be present.

Other Symptoms

Additional symptoms that can occur in individuals with Waldenstrom Macroglobulinemia include:

• Swollen ankles or legs: Fluid retention can lead to swelling in the lower extremities.


• Shortness of breath: Difficulty breathing or shortness of breath can occur due to anemia or fluid accumulation in the lungs.


• Recurrent infections: Individuals with WM may be more prone to infections due to the abnormal functioning of the immune system.


• Abnormal bleeding: In rare cases, WM can cause abnormal bleeding, such as gastrointestinal bleeding or blood in the urine.

If you are experiencing any of these symptoms or have concerns about your health, it is important to consult with a healthcare professional for a proper diagnosis and appropriate treatment.