Addison's disease, also known as primary adrenal insufficiency, is a rare and chronic endocrine disorder characterized by the insufficient production of hormones by the adrenal glands. These small glands, located on top of the kidneys, play a crucial role in producing hormones that are essential for regulating various bodily functions.
The condition is named after Dr. Thomas Addison, who first described it in 1855. Addison's disease occurs when the adrenal glands are damaged or destroyed, leading to a deficiency in cortisol and aldosterone production. Cortisol helps the body respond to stress, regulate metabolism, and maintain blood pressure, while aldosterone helps control the balance of salt and water in the body.
Some common synonyms for Addison's disease include:
The symptoms of Addison's disease can vary but often include fatigue, weight loss, muscle weakness, low blood pressure, darkening of the skin, and salt cravings. If left untreated, it can lead to a life-threatening adrenal crisis.
Diagnosis of Addison's disease involves blood tests to measure hormone levels, as well as imaging tests to assess the adrenal glands. Treatment typically involves hormone replacement therapy to restore the deficient hormones. Patients may need to take medications, such as hydrocortisone and fludrocortisone, for the rest of their lives.
It is important for individuals with Addison's disease to closely monitor their symptoms, follow their prescribed treatment plan, and wear a medical alert bracelet or necklace to alert healthcare professionals in case of emergencies.