Agenesis of Corpus Callosum (ACC) is a rare congenital brain disorder characterized by the partial or complete absence of the corpus callosum, the structure that connects the two hemispheres of the brain. ACC occurs in approximately 1 in 4,000 live births, making it a relatively uncommon condition.
The prevalence of ACC varies depending on the population studied and the diagnostic methods used. It is more commonly diagnosed in individuals with neurological or developmental disorders, such as autism spectrum disorder or intellectual disability. In these populations, the prevalence of ACC can be higher, ranging from 7% to 15%.
ACC can occur as an isolated condition or as part of a syndrome or genetic disorder. It is often associated with other brain abnormalities, such as ventriculomegaly or cortical malformations. The exact cause of ACC is not fully understood, but both genetic and environmental factors may play a role.
Early diagnosis and intervention are crucial for individuals with ACC to optimize their development and manage associated symptoms. Treatment typically involves a multidisciplinary approach, including therapies tailored to address specific challenges related to motor skills, communication, and social interaction.