Bilateral Renal Agenesis and Heredity
Bilateral Renal Agenesis (BRA) is a rare congenital condition characterized by the absence or underdevelopment of both kidneys in a fetus. It occurs when the kidneys fail to form during embryonic development. The condition is typically diagnosed during pregnancy or shortly after birth.
When it comes to the hereditary nature of BRA, research suggests that it is not directly inherited from parents. It is primarily considered a sporadic occurrence, meaning it happens by chance and is not passed down through generations. However, there have been a few reported cases where BRA appears to have a familial pattern, indicating a potential genetic component.
Studies have identified certain genetic mutations that may contribute to the development of BRA. These mutations affect genes involved in kidney development, such as the RET and GDNF genes. However, the exact inheritance pattern and specific genes involved in familial cases of BRA are not yet fully understood.
It is important to note that the majority of cases of BRA are not hereditary and occur randomly. The condition is often associated with other birth defects and genetic syndromes, such as Potter syndrome. Genetic counseling is recommended for families affected by BRA to better understand the potential risks and implications for future pregnancies.