Chronic Granulomatous Disease (CGD) is a rare genetic disorder that affects the immune system's ability to fight off certain types of bacterial and fungal infections. It is estimated that the prevalence of CGD is approximately 1 in 200,000 to 250,000 individuals worldwide. Although CGD can affect people of any age, it is usually diagnosed in early childhood.
CGD is caused by mutations in genes that are responsible for producing proteins involved in the immune system's response to infections. These mutations result in the inability of immune cells to produce reactive oxygen species, which are essential for killing bacteria and fungi. As a result, individuals with CGD are more susceptible to recurrent and severe infections, particularly in the lungs, skin, and other organs.
While CGD is a rare condition, it can have a significant impact on the quality of life and overall health of affected individuals. Early diagnosis and appropriate management, including antimicrobial therapy and stem cell transplantation, can help improve outcomes for individuals with CGD. Ongoing research and advancements in treatment options offer hope for better management and potential cures in the future.
by Diseasemaps