Febrile infection-related epilepsy syndrome (FIRES) is a rare and severe form of epilepsy that primarily affects children and young adults. It is characterized by the sudden onset of prolonged seizures, often triggered by a febrile infection. FIRES is a devastating condition with a high morbidity and mortality rate.
The prevalence of FIRES is difficult to determine due to its rarity. However, it is estimated to affect approximately 1 in 100,000 individuals. The syndrome typically occurs in previously healthy individuals, with an average age of onset between 3 and 15 years. Boys are slightly more affected than girls.
FIRES is a medical emergency that requires intensive care and aggressive treatment. The seizures associated with FIRES are often resistant to standard antiepileptic medications, making management challenging. The long-term prognosis for individuals with FIRES is variable, with some experiencing significant cognitive and neurological impairments.
Research and understanding of FIRES are still limited, and further studies are needed to unravel its underlying causes and develop more effective treatments. The rarity of the condition emphasizes the importance of raising awareness and supporting affected individuals and their families.