Fibrous Dysplasia is a rare bone disorder characterized by the abnormal growth of fibrous tissue in place of normal bone. It is considered a non-inherited condition, typically caused by a sporadic mutation in the GNAS gene. The prevalence of Fibrous Dysplasia varies depending on the specific population being studied.
While exact prevalence rates are challenging to determine due to the rarity of the condition, it is estimated that Fibrous Dysplasia affects approximately 1 in 30,000 to 1 in 100,000 individuals worldwide. The disorder can occur in both males and females of any age, but it is most commonly diagnosed in childhood or adolescence.
Fibrous Dysplasia can affect a single bone (monostotic) or multiple bones (polyostotic), and it may be associated with other conditions such as McCune-Albright syndrome. The bones commonly affected include the skull, facial bones, long bones, and pelvis. Symptoms can vary widely, ranging from mild bone pain and deformities to fractures and functional impairments.
Diagnosis of Fibrous Dysplasia involves a combination of clinical evaluation, imaging techniques (such as X-rays, CT scans, or MRI), and sometimes genetic testing. Treatment options aim to manage symptoms and complications, and may include medications, surgery, or other interventions tailored to the individual's needs.
While Fibrous Dysplasia is a rare condition, raising awareness among healthcare professionals and the general public is crucial for early detection, appropriate management, and support for affected individuals.