GM1 Gangliosidosis is a rare genetic disorder that affects the nervous system. It is caused by a deficiency of an enzyme called beta-galactosidase, which leads to the accumulation of a specific type of fat called GM1 ganglioside in the body's cells. This buildup primarily affects the brain and spinal cord.
The prevalence of GM1 Gangliosidosis is estimated to be around 1 in 100,000 to 200,000 live births worldwide. However, the exact prevalence may vary among different populations and regions. The disorder can occur in individuals of any ethnic background.
GM1 Gangliosidosis is classified into three main types: infantile, juvenile, and adult-onset. The infantile form is the most severe and typically presents within the first few months of life. The juvenile and adult-onset forms have a later onset and milder symptoms.
Although GM1 Gangliosidosis is a rare condition, it can have a significant impact on affected individuals and their families. Early diagnosis and supportive care are crucial in managing the symptoms and improving the quality of life for those affected by this disorder.