Hyper IgE Syndrome, also known as Job's syndrome, is a rare genetic disorder that affects the immune system. It is characterized by abnormally high levels of Immunoglobulin E (IgE) antibodies in the blood, leading to recurrent infections, eczema, and various other symptoms.
Individuals with Hyper IgE Syndrome often experience frequent and severe bacterial and fungal infections, particularly of the skin, lungs, and sinuses. These infections can be difficult to treat and may recur frequently. Additionally, affected individuals may have chronic eczema, which is a skin condition characterized by itchy, inflamed, and dry patches of skin.
Hyper IgE Syndrome is caused by mutations in certain genes that play a role in the immune system's response to infections. It is typically inherited in an autosomal dominant pattern, meaning that a person only needs to inherit one copy of the mutated gene from either parent to develop the condition.
Diagnosis of Hyper IgE Syndrome involves a combination of clinical evaluation, medical history analysis, and laboratory tests to measure IgE levels. Treatment focuses on managing infections, controlling eczema symptoms, and preventing complications. This may involve the use of antibiotics, antifungal medications, and immunomodulatory drugs.
While there is no cure for Hyper IgE Syndrome, with proper management and care, individuals with the condition can lead fulfilling lives.