Limb-girdle muscular dystrophy (LGMD) is a group of genetic disorders that primarily affect the muscles in the hips and shoulders. It is characterized by progressive muscle weakness and wasting, leading to difficulties in walking, climbing stairs, and performing everyday tasks.
The prevalence of LGMD varies depending on the specific subtype. There are currently more than 30 known subtypes of LGMD, each caused by mutations in different genes. Some subtypes are more common than others.
Overall, the prevalence of LGMD is estimated to be around 1 in 14,500 to 1 in 123,000 individuals worldwide. However, it is important to note that these figures may vary across different populations and geographic regions.
LGMD can affect individuals of any age, gender, or ethnic background. Symptoms usually appear in late childhood, adolescence, or adulthood, but the age of onset and disease progression can vary widely. Some subtypes of LGMD may have a more severe course, while others may be relatively milder.
Due to the genetic nature of LGMD, it can be inherited in an autosomal recessive or autosomal dominant manner. Genetic counseling and testing are crucial for individuals and families affected by LGMD to understand the specific subtype and inheritance pattern.