Nephrogenic diabetes insipidus (NDI) is a rare disorder characterized by the inability of the kidneys to concentrate urine, leading to excessive thirst and frequent urination. It is estimated that the prevalence of NDI is approximately 1 in 20,000 to 1 in 250,000 individuals worldwide.
NDI can be either acquired or inherited. Acquired NDI can occur as a result of certain medications, such as lithium, or as a complication of other conditions like chronic kidney disease. Inherited NDI is caused by mutations in specific genes involved in the regulation of water balance in the kidneys.
The prevalence of acquired NDI is higher compared to inherited NDI. Acquired NDI can affect individuals of any age, while inherited NDI is typically present from birth or early childhood. The exact prevalence of each type of NDI is difficult to determine due to its rarity and the variability in symptoms among affected individuals.
Early diagnosis and appropriate management are crucial for individuals with NDI. Treatment options include medications to reduce urine output and increase water reabsorption, as well as dietary modifications to maintain hydration. Regular monitoring and follow-up with healthcare professionals are essential to manage the condition effectively.