Is Osteonecrosis hereditary?

Here you can see if Osteonecrosis can be hereditary. Do you have any genetic components? Does any member of your family have Osteonecrosis or may be more predisposed to developing the condition?


Osteonecrosis, also known as avascular necrosis, is a condition that occurs when there is a temporary or permanent loss of blood supply to the bones, leading to bone death. It commonly affects the hip, knee, shoulder, and other joints.



When it comes to the hereditary nature of osteonecrosis, there is limited evidence to suggest a direct genetic link. Osteonecrosis is primarily caused by various risk factors such as trauma, long-term use of corticosteroids, excessive alcohol consumption, certain medical conditions (such as sickle cell disease), and certain medical treatments (such as radiation therapy). These factors can disrupt the blood supply to the bones, resulting in osteonecrosis.



While there is no clear evidence of a hereditary component, it is important to note that some medical conditions associated with osteonecrosis can have a genetic basis. For example, sickle cell disease, which increases the risk of osteonecrosis, is an inherited blood disorder caused by a mutation in the hemoglobin gene. However, the development of osteonecrosis itself is not directly inherited.



It is crucial to consult with a healthcare professional if you suspect you may have osteonecrosis or have concerns about your risk factors. They can evaluate your medical history, conduct necessary tests, and provide appropriate guidance and treatment options based on your individual circumstances.


by Diseasemaps

Don't think so.

6/16/17 by Austin 4830

General not classified as hereditary but some evidence supports a role for genetic factors in some avascular necrosis suggesting that gene mutations could play a role in the pathogenesis of osteonecrosis.

6/30/17 by Dave 2270

It might be, but there isn't any evidence that that is the only cause.

11/3/17 by Pamela 1600

Some implicating factors are heriditary.

6/11/18 by Rob 1500

No i don’t think and no I don’t think either.

6/11/18 by Megan 2500

Recent research suggests that AVN/Osteonecrosis may be hereditary. Because of the mechanics of the disease and it’s extreme rarity, this subject is being researched more often.

11/13/18 by Scott 3050

There isn’t an answer to that question. Genetics are being researched as AVN being hereditary.

8/27/19 by Cheryl 2800

The diseases that lead to AVN can be

2/28/20 by Lisa j 1700

Research suggests that people whose blood clots more easily may be predisposed to have osteonecrosis. Clotting can be affected by heritable conditions (like sickle cell disease), acquired conditions (like high blood lipid levels) and genetic abnormalities. None of these factors on their own causes osteonecrosis but having them may increase the likelihood of acquiring it.

3/15/20 by Caitlin 3050

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