What is the prevalence of Small Fiber Neuropathy?

How many people does Small Fiber Neuropathy affect? Does it have the same prevalence in men and women? And in the different countries?


Small Fiber Neuropathy (SFN) is a relatively common disorder affecting the peripheral nervous system. It is characterized by damage to the small nerve fibers responsible for transmitting sensory information, leading to various symptoms.


The prevalence of SFN varies depending on the population studied and the diagnostic criteria used. However, research suggests that SFN is not uncommon, with estimates ranging from 52 to 364 cases per 100,000 individuals. It is important to note that SFN is often underdiagnosed or misdiagnosed due to its diverse symptoms and lack of awareness among healthcare professionals.


Common symptoms of SFN include: burning or tingling sensations, numbness, pain, and hypersensitivity to touch or temperature changes. These symptoms typically affect the hands and feet but can also involve other areas of the body.


While the exact cause of SFN is often unknown, it can be associated with various underlying conditions such as diabetes, autoimmune disorders, infections, and genetic mutations.


Early diagnosis and appropriate management are crucial to prevent further nerve damage and improve quality of life for individuals with SFN. If you suspect you may have SFN, it is important to consult a healthcare professional for proper evaluation and guidance.


by Diseasemaps

In 2013 the NIH put SFN prevalence at 52 cases her 100,000 people which is about .05% of the population, but since then there has been more and better testing so that number has likely increased.

7/12/21 by Jo 3150

According to Harvard and Stanford Neurology and UCSF, 1 in 1,000,000

2/3/22 by Mark 2000

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