Waldenstrom Macroglobulinemia (WM) is a rare type of cancer that affects the bone marrow and lymphatic system. It is classified as a type of non-Hodgkin lymphoma and is characterized by the overproduction of abnormal white blood cells called lymphoplasmacytic cells.
WM is primarily caused by a genetic mutation that leads to the uncontrolled growth of these abnormal cells. These cells produce excessive amounts of a protein called monoclonal immunoglobulin M (IgM), which can accumulate in the blood and cause various symptoms.
Common symptoms of WM include fatigue, weakness, weight loss, enlarged lymph nodes, and bleeding problems due to low platelet count. The disease progresses slowly, and its severity can vary from person to person.
Diagnosis of WM involves blood tests, bone marrow biopsy, and imaging tests to assess the extent of the disease. Treatment options depend on the individual's age, overall health, and the stage of the disease. Some common treatments include chemotherapy, targeted therapy, immunomodulatory drugs, and stem cell transplantation.
While there is no cure for WM, ongoing treatment can help manage the symptoms and slow down the progression of the disease. Regular monitoring and follow-up with healthcare professionals are crucial for individuals with WM.