CRPS Complex Regional Pain Syndrome and depression

Can CRPS Complex Regional Pain Syndrome cause depression? Could it affect your mood? Find out how CRPS Complex Regional Pain Syndrome can affect your mood.


CRPS (Complex Regional Pain Syndrome) and Depression


Complex Regional Pain Syndrome (CRPS) is a chronic pain condition that typically affects one limb, often after an injury or trauma. It is characterized by intense and prolonged pain, changes in skin color and temperature, swelling, and sensitivity to touch. CRPS can have a significant impact on a person's physical and emotional well-being, often leading to the development of comorbid conditions such as depression.



Depression is a mental health disorder characterized by persistent feelings of sadness, hopelessness, and a loss of interest in activities. It can affect a person's mood, thoughts, and behavior, leading to a variety of emotional and physical symptoms. Depression is a common comorbidity in individuals with chronic pain conditions, including CRPS.



The relationship between CRPS and depression is complex and multifaceted. The chronic and debilitating nature of CRPS can significantly impact a person's quality of life, leading to feelings of frustration, helplessness, and despair. The constant pain and physical limitations can disrupt daily activities, social interactions, and employment, which can contribute to the development of depression.



Psychological factors also play a role in the development of depression in individuals with CRPS. The experience of chronic pain can lead to negative thoughts and beliefs about oneself, the future, and the world. The constant pain can erode a person's self-esteem and sense of control, leading to feelings of worthlessness and hopelessness. Additionally, the fear of exacerbating pain or triggering a flare-up can lead to avoidance behaviors and social isolation, further contributing to depressive symptoms.



Biological factors may also contribute to the development of depression in individuals with CRPS. Chronic pain conditions like CRPS can disrupt the normal functioning of the nervous system, leading to imbalances in neurotransmitters such as serotonin and norepinephrine, which are implicated in mood regulation. These imbalances can contribute to the development of depressive symptoms.



Treatment for individuals with both CRPS and depression typically involves a multidisciplinary approach. It may include a combination of medication, psychotherapy, physical therapy, and other complementary therapies. Medications such as antidepressants can help regulate mood and alleviate depressive symptoms. Psychotherapy, such as cognitive-behavioral therapy (CBT), can help individuals develop coping strategies, challenge negative thoughts, and improve their overall well-being.



Support from healthcare professionals, family, and friends is crucial for individuals with CRPS and depression. Having a strong support system can provide emotional validation, practical assistance, and encouragement throughout the treatment process. Support groups and online communities can also be valuable resources for individuals to connect with others who are experiencing similar challenges.



It is important to seek professional help if you or someone you know is experiencing symptoms of CRPS and depression. A healthcare provider can provide an accurate diagnosis, develop an appropriate treatment plan, and offer support throughout the recovery process.


by Diseasemaps

When pain flares arise , one feels totally alone and distraught. A blue mood is easy to develope because one with draws and feels helpless.

11/19/17 by norma.mark@icloud.com 5060

It’s in moments like these when my pain flares are so uncontrollable and renders me absolutely helpless that I feel myself spiralling down a large big black hole. I cry inwardly , no one sees , no one hears the pain. I ‘m not cut, their are no bruises , it’s so hard to explain to others .I ‘m a dry ,I’m sad , I feel isolated, I feel alone. I lay in my bed , the covers hold no comfort as they seem to burn my skin.My feet are tingly and blue . 4-5 days of sheer hell , sleepless nights and I am weary and tired again.. There is no relief in sight and this silent monster is off the lead again but I have no energy to catch it and put it back on the lead.

6/10/18 by Misty 2100

Indeed it can. Depression is a common occurrence. Dealing with constant pain, and being acutely sleep deprived, takes it's toll. I lost my job because of this. Feeling like a burden to my family and friends fills me with shame. It is a constant struggle to find purpose and value. Seeking help for this portion is as vital as all other aspects of this disease!!!!

11/1/18 by Judy 3000

Yes CRPS can contribute to depression. Many end up with depression due to the pain and not being able to do what they use to. We often lose friends and family members due to the CRPS which will also lead to depression. The pain will eventually make you want to not go out any more if you let it. You become lonely and sad because of what you have lost and then certain pain medications will add to those feelings. It is a terrible circle that just gets darker and darker and hurts even more! It is very hard to pull yourself out of that Dark hole without help with talking to someone and antidepressants to help. But many have done it so yes it can be done. I am one of them.

1/5/19 by Cynthia 4000

Sounds lights people all can get on ones nerves more easily. All your pain is on high alert and dealing with wanting to be alone and with others is a hard balance.

1/16/21 by Patricia 3050

The area of the brain that sends pain signals is extremely close to the lumber system. This is the system responsible for depression.

3/19/21 by Melanie 1200

Roughly 16% of patients with Complex Regional Pain Syndrome also had a diagnoses of depression. The hardest thing to deal with is managing the pain and finding the strength to do simple tasks and work.

3/29/21 by Sage0920 2000

Chronic pain often leads to depression and stress increases pain. Definitely true.

11/3/22 by Heather 5020

Top questions

What is the life expectancy of someone with CRPS Complex Regional Pain Synd...

Celebrities with CRPS Complex Regional Pain Syndrome

Is CRPS Complex Regional Pain Syndrome hereditary?

Is CRPS Complex Regional Pain Syndrome contagious?

Is there any natural treatment for CRPS Complex Regional Pain Syndrome?

View more questions of CRPS Complex Regional Pain Syndrome

World map of CRPS Complex Regional Pain Syndrome


Find people with CRPS Complex Regional Pain Syndrome through the map. Connect with them and share experiences. Join the CRPS Complex Regional Pain Syndrome community.

There are 1724 people in the map. View Map of CRPS Complex Regional Pain Syndrome