Factor V Leiden is a genetic mutation that affects the clotting factor V in the blood, making individuals more prone to abnormal blood clot formation. It is the most common inherited thrombophilia, or blood clotting disorder, among individuals of European descent.
The prevalence of Factor V Leiden varies among different populations. In individuals of European ancestry, it is estimated to affect around 5% of the population. However, the prevalence can be significantly lower in other ethnic groups, such as African, Asian, and Native American populations.
Factor V Leiden is more commonly found in individuals with a personal or family history of blood clots. It is also more prevalent in individuals who have experienced deep vein thrombosis (DVT), pulmonary embolism, or recurrent miscarriages.
It is important to note that not everyone with the Factor V Leiden mutation will develop blood clots, as other factors such as lifestyle, medical conditions, and additional genetic variations can influence the risk. Genetic testing can help identify individuals with this mutation, allowing for appropriate preventive measures and treatment strategies.