What is the prevalence of HFE hereditary haemochromatosis?

How many people does HFE hereditary haemochromatosis affect? Does it have the same prevalence in men and women? And in the different countries?


HFE hereditary haemochromatosis is a genetic disorder characterized by excessive absorption of dietary iron, leading to iron overload in various organs. It is considered one of the most common genetic disorders in people of European descent. The prevalence of HFE hereditary haemochromatosis varies among different populations.



In Caucasians of Northern European descent, the prevalence is estimated to be around 1 in 200 individuals. However, it is important to note that not all individuals with the HFE gene mutation will develop symptoms or complications associated with iron overload.



Although less common, HFE hereditary haemochromatosis can also occur in individuals of other ethnic backgrounds, including African, Asian, and Hispanic populations. The prevalence in these populations is generally lower compared to Caucasians.



Early diagnosis and treatment are crucial in managing HFE hereditary haemochromatosis. Genetic testing and regular monitoring of iron levels can help identify individuals at risk and prevent complications associated with iron overload.


by Diseasemaps

HFE Hereditary haemochromatosis is generally found only in Caucasian races with higher prevalence in people of northern European (Scandinavian and Celtic) origins. In Ireland, the genetic risk is about 1 in 80. In other northern European countries and countries with high levels of European migration like Australia, Canada, USA, New Zealand, South Africa and Brazil the prevalence is quite high. In Australia for instance, the risk is about 1 in 200.

5/21/17 by Tony Moorhead 2051

Since I am not into haematology I don't know anything about the prevalence of HFE hereditary haemochromatosis.

6/4/17 by bewiki 4317

HH is extremely common. Some numbers indicate 1 in 200 people in the US may have it. Even more prevalent in Ireland.

7/22/17 by Salena 2001

One in 200 people have hemachromatosis

7/23/17 by Warbychick 1901

In North Western Europe the prevalence of HFE HH is about 0.5-.0.7 % for the caucasian population.

7/25/17 by Ketil Toska 2051

Its prevalence is estimated to be 3–5/1000 in Caucasians. A single mutation, C282Y in the HFE gene explains 80–90% of all diagnosed cases in populations of northwestern European ancestry. The importance of another frequent mutation in this gene, H63D, as well as of C282Y/H63D compound heterozygotes, is still a matter of debate

8/2/17 by Natalie 2000

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