Multiple Endocrine Neoplasia (MEN) is a rare genetic disorder characterized by the development of tumors in multiple endocrine glands. There are three main types of MEN: MEN1, MEN2A, and MEN2B, each associated with specific gene mutations.
MEN1 is the most common type, with an estimated prevalence of 1 in 30,000 individuals. It typically manifests with tumors in the parathyroid glands, pancreas, and pituitary gland. MEN2A and MEN2B are less common, with a prevalence of approximately 1 in 35,000 and 1 in 1 million, respectively. These types primarily involve tumors in the thyroid gland and adrenal glands.
Although MEN is considered rare, it is important to note that prevalence rates may vary across different populations. Additionally, due to its genetic nature, MEN can be inherited within families, increasing the likelihood of occurrence in certain lineages.
Early diagnosis and appropriate management are crucial in MEN to prevent complications and improve outcomes. Regular screenings and genetic testing are recommended for individuals with a family history of MEN or related symptoms.