What are the best treatments for Narcolepsy?

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Treatments for Narcolepsy


Narcolepsy is a chronic neurological disorder that affects the brain's ability to regulate sleep-wake cycles. People with narcolepsy often experience excessive daytime sleepiness, sudden and uncontrollable sleep attacks, and disrupted nighttime sleep. While there is no cure for narcolepsy, several treatments can help manage its symptoms and improve the quality of life for individuals living with this condition.



1. Medications


Stimulants: Stimulant medications are commonly prescribed to help individuals with narcolepsy stay awake during the day. These medications, such as modafinil and armodafinil, work by increasing alertness and reducing excessive daytime sleepiness. They can significantly improve wakefulness and help individuals maintain a normal sleep-wake schedule.


Sodium Oxybate: Sodium oxybate, also known as gamma-hydroxybutyrate (GHB), is a medication that can help improve nighttime sleep and reduce the frequency of cataplexy attacks. It is usually taken in two doses, one at bedtime to improve sleep quality and the other during the night to reduce the occurrence of cataplexy.


Antidepressants: Certain antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), can be prescribed to manage symptoms of cataplexy, sleep paralysis, and hallucinations associated with narcolepsy.



2. Lifestyle Modifications


Regular Sleep Schedule: Maintaining a consistent sleep schedule is crucial for individuals with narcolepsy. Going to bed and waking up at the same time every day can help regulate sleep patterns and reduce excessive daytime sleepiness.


Napping: Short, scheduled naps throughout the day can help manage sleepiness and improve alertness. These power naps should be strategically planned to avoid interfering with nighttime sleep.


Avoidance of Triggers: Identifying and avoiding triggers that worsen narcolepsy symptoms can be beneficial. These triggers may include alcohol, caffeine, heavy meals, and stressful situations.


Regular Exercise: Engaging in regular physical activity can help improve overall sleep quality and reduce daytime sleepiness. However, it is important to avoid exercising too close to bedtime, as it may interfere with nighttime sleep.



3. Behavioral Therapy


Cognitive Behavioral Therapy (CBT): CBT can be helpful in managing the emotional and psychological impact of narcolepsy. It focuses on identifying and changing negative thought patterns and behaviors that may contribute to sleep disturbances and excessive daytime sleepiness.


Nap Management: Learning effective nap strategies, such as scheduled and controlled napping, can help individuals with narcolepsy manage their sleepiness and improve alertness throughout the day.


Education and Support: Joining support groups or seeking counseling can provide individuals with narcolepsy the opportunity to connect with others facing similar challenges. Sharing experiences and coping strategies can be empowering and help improve overall well-being.



4. Other Therapies


Experimental Treatments: In some cases, individuals with narcolepsy may participate in clinical trials or experimental treatments. These may include new medications, therapies, or devices that aim to improve symptoms and better manage the condition.


Alternative Therapies: Some individuals find complementary and alternative therapies helpful in managing narcolepsy symptoms. These may include acupuncture, yoga, meditation, and herbal supplements. However, it is important to consult with healthcare professionals before trying any alternative treatments.



It is important for individuals with narcolepsy to work closely with healthcare professionals to develop a personalized treatment plan. Treatment approaches may vary depending on the severity of symptoms and individual needs. With the right combination of medications, lifestyle modifications, and support, individuals with narcolepsy can effectively manage their symptoms and lead fulfilling lives.


by Diseasemaps

Dexamphetamine has worked best for me. Unfortunately most of the other medications either didn't work, or are not available in my country.

3/2/17 by Rachael 1050

Modafinil and lifestyle changes

3/2/17 by Sarah 1000

Stimulants and Nighttime Sleep Aids (Ex: Adderall and Xyrem)

4/27/17 by Jennah 1100

For quality sleep: Xyrem. For wakefulness: Stimulants-Nuvigil/Provigil.

4/28/17 by Emily 1115

It's very individually but the medication iI take is: Lisdexamfetamine (amphetamine) Modafinil (stimulants) Fluoxetine (antidepressant)

5/7/17 by Malin 1050

It depends.. some medication help for some people but don't for others. I take Elvanse (dexamfetamine), venlafaxine (antidepressant) and Medikinet (a kind of ADHD-medicine). Many skip carbs and sugar and think that helps to. Exercising is very good as always.

5/7/17 by 450

Xyrem is the best followed by stimulants.

5/10/17 by Susan 1000

Xyrem: highly controlled substance, but it is life-changing for some people when they reach the correct dosage. Reduces REM sleep. Adderall: temporary fix for the daytime sleepiness. It can help someone not fall asleep or to better be able to focus. Modafinal:keeps you awake during the day, but gave me massive migraines. Baclofen: people have said that this medicine helps them sleep.

6/3/17 by Tabbij13 830

Medication ....stimulants modafinal and dexamphedamine

6/12/17 by Faith 2000

Nuvigil and Xyrem. I take Nuvigil and my adult daughter takes it along with Xyrem

6/13/17 by Karen 2000

Melatonin at night Vitamin B12 in the morning 200 my provigil in the morning

8/17/17 by Laurie 2271

For the sleepiness I usually take (4) 10 mg dextro-amphetamine tablets and at least 2 brief naps. For the cataplexy I usually take (2) 20mg fluoxetine capsules.

9/26/17 by joyce 200

Medication and support.

10/6/17 by Aaron 2811

Every treatment affects each individual differently. A medication that is an absolute miracle for one patient, may have no affect at all for another. Treatment seems to be trial and error for most Sleep Specialists. If I may use myself as an example, I can say that my medications were changed by my Doctor every thirty days for the first five months following my initial diagnosis. Now I am prescribed two Central Nervous Stimulants twice each day and I STILL must take daily naps... Primarily there are three popular methods for the attempted treatment of Narcolepsy: 1) Stimulants in Pill Form 2) Sleep Aids (Xyrem seems to be prescribed most often and is a highly regulated sleep inducer with very strict rules regarding it's dosage and distribution. (From the Single Manufacturer!) 3) Sleep & Nap Scheduling - Some patients elect to refrain from a treatment involving medication and instead schedule a solid block of night-time sleep in conjunction with regular naps throughout the day. Many Doctors use a combination of these methods.

10/26/17 by Jen W 200

Currently the best treatments are stimulants and medications like Nuvigil and Provigil during the day to aid wakefulness along with xyrem at night to help with cataplexy, sleep paralysis and Hypnagogic Hallucinations. Ptilosant (wakix) and an extended release sodium oxybate are two meds that are being studied as alternatives. There is no cure currently.

10/26/17 by Cyn 610

At the moment you can only use treatments for the synptoms. Modafinil or Metilfenidate for awaking the patients, Sodium Oxibat for the cataleptic atacks And anti -depressive medication such as anafranil, fluoxetine, sertraline, etc Theres a new drug pitolisant that is very expensive there are only in a few countries and is a acts as an inverse agonist/antagonist at the h3 (histamine) receptor.

11/21/17 by sns 1510

For me, the most effective treatment has been modafinil for the first ten years after I was diagnosed. Followed by Nuvigil (armodafinil) for the next five years. Xyrem has been effective for some people to help with the interrupted sleep, particularly for those who also have cataplexy. Other medications include Adderal and Ritalin.

5/21/18 by chazer25 3050

Treatments are different for everyone. It’s important to find a sleep specialist that will work with you. What has worked for me is Vyvance in the morning, Provigil twice a day, once in the morning and between1-2 in the evening, and Xyrem taken in two doses at night. Normally taken for me 10pm and 1am.

7/7/18 by Casey Veater 1100

So far taking Dextroamphetamine.

4/16/19 by KLebal 300

Xyrem or xywave are life changing

10/13/21 by corbinhope101@gmail.com 1700

Medication Lifestyle adjustments Mental health care

10/13/21 by MandyW 600

Night time treatments like sodium oxybate

7/13/23 by Feri Ascencion 1833
Translated from spanish Improve translation

at this moment we are testing with Xiren

4/27/17 by marisa rosello. Translated
Translated from spanish Improve translation

Modafinil is usually enough to keep you awake. In resistant cases are used derivatives of amphetamines, always after a sleep test.

11/2/17 by Juan. Translated

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