What are the best treatments for Desmoid Tumor?

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Desmoid tumors are rare, locally aggressive tumors that arise from connective tissue cells. They can occur in any part of the body, but are most commonly found in the abdominal wall, shoulder, and thigh. Desmoid tumors can be challenging to treat due to their unpredictable growth patterns and tendency to invade surrounding structures. The optimal treatment approach depends on various factors, including tumor size, location, and patient preferences.



Watchful waiting: In some cases, particularly when the tumor is small and not causing symptoms, a watchful waiting approach may be recommended. Regular monitoring through imaging tests such as MRI or CT scans can help track the tumor's growth and determine if intervention is necessary.



Surgery: Surgical resection is often considered the primary treatment for desmoid tumors. However, complete removal can be difficult due to the tumor's infiltrative nature and proximity to vital structures. In cases where complete resection is feasible, surgery can offer a potential cure. However, there is a risk of recurrence, and close follow-up is necessary.



Radiation therapy: Radiation therapy may be used as an adjunct to surgery or as a primary treatment option for inoperable or recurrent desmoid tumors. It involves the use of high-energy X-rays to target and destroy cancer cells. Radiation therapy can help reduce tumor size, relieve symptoms, and improve local control.



Systemic therapy: For patients with unresectable or recurrent desmoid tumors, systemic therapy may be considered. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac and tamoxifen, which are typically used for other conditions, have shown some efficacy in treating desmoid tumors. Other systemic treatment options include targeted therapies like tyrosine kinase inhibitors (e.g., imatinib) and anti-hormonal agents (e.g., toremifene).



Chemotherapy: Traditional chemotherapy drugs, such as doxorubicin and methotrexate, have limited effectiveness in treating desmoid tumors. However, they may be used in combination with other treatment modalities or in cases where other options have failed.



Novel therapies: Research is ongoing to explore new treatment approaches for desmoid tumors. These include the use of molecularly targeted therapies, immunotherapies, and novel drug combinations. Clinical trials may be available for patients who are interested in participating and potentially accessing innovative treatments.



Supportive care: Desmoid tumor treatment can be physically and emotionally challenging. Supportive care, including pain management, physical therapy, and psychological support, plays a crucial role in improving the quality of life for patients.



It is important for patients with desmoid tumors to consult with a multidisciplinary team of healthcare professionals, including surgeons, radiation oncologists, medical oncologists, and pathologists, to determine the most appropriate treatment plan. Each case is unique, and treatment decisions should be tailored to individual circumstances and preferences.


by Diseasemaps
Translated from spanish Improve translation

Radiotherapy, tamoxifen, and chemotherapy

9/6/17 by Maria. Translated

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