Is Adult Polyglucosan Body Disease (APBD) contagious?

Adult Polyglucosan Body Disease (APBD) is a rare genetic disorder that affects the nervous system. It is caused by a mutation in the GBE1 gene, which leads to the accumulation of abnormal glycogen in the body's cells. APBD primarily affects adults, typically appearing between the ages of 40 and 60.

As a genetic disorder, APBD is not contagious. It is not caused by exposure to any infectious agents or transmitted from person to person. The condition is inherited in an autosomal recessive manner, meaning that an individual must inherit two copies of the mutated gene (one from each parent) to develop the disease.

The symptoms of APBD can vary widely, but commonly include progressive weakness and stiffness in the legs, difficulty walking, bladder and bowel dysfunction, and cognitive impairment. The disease progresses slowly over time and can significantly impact an individual's quality of life.

While APBD is not contagious, it is important for individuals with a family history of the disease to undergo genetic counseling and testing. This can help determine their risk of passing the mutated gene to their children and provide information for family planning decisions.

In conclusion, Adult Polyglucosan Body Disease (APBD) is a non-contagious genetic disorder that primarily affects adults. It is caused by a mutation in the GBE1 gene and is inherited in an autosomal recessive manner. Genetic counseling and testing are recommended for individuals with a family history of APBD.