Common Variable Immunodeficiency (CVID) is a medical condition characterized by a weakened immune system, leading to recurrent infections and an increased susceptibility to various diseases. This disorder is also known by several other names, including Hypogammaglobulinemia, Adult-Onset Immunodeficiency Syndrome, and Acquired Hypogammaglobulinemia.
CVID is a primary immunodeficiency disorder, meaning it is not caused by any other underlying condition. It typically manifests in adolescence or adulthood, with symptoms varying widely among individuals. The primary feature of CVID is a deficiency in the production of antibodies, specifically immunoglobulins, which are crucial for fighting off infections.
People with CVID often experience recurrent respiratory tract infections, such as sinusitis, bronchitis, and pneumonia. They may also be prone to gastrointestinal infections, skin infections, and autoimmune disorders. Additionally, individuals with CVID have an increased risk of developing certain cancers, particularly lymphomas and gastric cancer.
The exact cause of CVID is not yet fully understood, but it is believed to involve a combination of genetic and environmental factors. In some cases, specific gene mutations have been identified, while in others, the cause remains unknown. Diagnosis of CVID involves a thorough evaluation of a person's medical history, physical examination, and laboratory tests to assess immunoglobulin levels.
Treatment for CVID primarily focuses on managing symptoms and preventing infections. This often involves regular infusions of immunoglobulin replacement therapy to boost the immune system. Antibiotics may be prescribed to treat and prevent infections. Additionally, individuals with CVID are advised to practice good hygiene, receive recommended vaccinations, and avoid exposure to potential pathogens.
Living with CVID can present challenges, but with proper medical care and support, individuals can lead fulfilling lives. It is important for individuals with CVID to work closely with healthcare professionals to develop a personalized treatment plan and to stay vigilant in managing their health.