Darier's disease synonyms

Darier's Disease Synonyms

Darier's disease, also known as Darier-White disease or keratosis follicularis, is a rare genetic skin disorder that affects the skin, nails, and mucous membranes. It is named after the French dermatologist Ferdinand-Jean Darier, who first described the condition in 1889.

Synonyms for Darier's disease include:

• Darier-White disease: This name is derived from the collaboration between Darier and White, an American dermatologist who independently described the condition in 1896.


• Keratosis follicularis: This term refers to the characteristic feature of the disease, which is the formation of small, rough bumps on the skin known as keratotic papules.


• Dyskeratosis follicularis: This synonym emphasizes the abnormal keratinization process that occurs in the hair follicles and other affected areas.


• Acrokeratosis verruciformis of Hopf: This name is used to describe a variant of Darier's disease that primarily affects the hands and feet, causing wart-like growths.


• Autosomal dominant keratosis follicularis: This term highlights the genetic inheritance pattern of the disease, as it is passed down from one generation to another in an autosomal dominant manner.

Darier's disease is characterized by a range of symptoms, including skin lesions, nail abnormalities, and mucosal involvement. The condition can vary in severity, with some individuals experiencing mild symptoms while others have more extensive and debilitating manifestations. It is caused by mutations in the ATP2A2 gene, which is responsible for the production of a protein involved in calcium regulation within cells.

While there is currently no cure for Darier's disease, various treatment options can help manage the symptoms and improve the quality of life for affected individuals. These may include topical medications, oral retinoids, and other supportive measures.