What is the prevalence of Pachyonychia Congenita?
How many people does Pachyonychia Congenita affect? Does it have the same prevalence in men and women? And in the different countries?
Pachyonychia Congenita is a rare genetic disorder characterized by thickened nails and other skin abnormalities. It is estimated to affect approximately 1 in 10,000 to 1 in 100,000 individuals worldwide. The prevalence may vary among different populations and regions. Pachyonychia Congenita is inherited in an autosomal dominant manner, meaning that an affected individual has a 50% chance of passing the condition to each of their children. Diagnosis and management of this condition require a multidisciplinary approach involving dermatologists, geneticists, and other healthcare professionals.
Pachyonychia Congenita (PC) is a rare genetic disorder that affects the nails and skin. It is estimated to have a prevalence of approximately 1 in 50,000 to 1 in 100,000 individuals worldwide. PC is characterized by thickened nails (pachyonychia) and painful calluses on the soles of the feet (plantar keratoderma), among other symptoms.
There are four subtypes of PC, each caused by a mutation in a different gene. The most common subtype is PC-1, followed by PC-2, PC-3, and PC-4. The prevalence of each subtype varies, with PC-1 being the most prevalent.
PC is typically present from birth and can significantly impact the quality of life for affected individuals. The severity of symptoms can vary widely, even among individuals with the same subtype. PC is a lifelong condition that requires ongoing management and treatment to alleviate symptoms and improve quality of life.
While PC is considered a rare disorder, it is important to raise awareness about it to ensure early diagnosis and appropriate support for affected individuals and their families.
