Is it advisable to do exercise when affected by PEPCK Deficiency? Which activities would you suggest and how intense should they be?

PEPCK Deficiency is a rare genetic disorder that affects the production of an enzyme called phosphoenolpyruvate carboxykinase (PEPCK). This enzyme plays a crucial role in the process of gluconeogenesis, which is the production of glucose from non-carbohydrate sources in the body. Individuals with PEPCK Deficiency have impaired gluconeogenesis, leading to low blood sugar levels and various symptoms such as hypoglycemia, fatigue, and muscle weakness.

When it comes to exercise and PEPCK Deficiency, it is important to approach physical activity with caution. The primary concern is the risk of hypoglycemia, as individuals with PEPCK Deficiency already have difficulty maintaining normal blood sugar levels. Engaging in intense or prolonged exercise can further deplete glucose stores and exacerbate symptoms.

However, this does not mean that individuals with PEPCK Deficiency should avoid exercise altogether. In fact, regular physical activity can have numerous benefits for overall health and well-being. It is crucial to find a balance between staying active and managing the risk of hypoglycemia.

Low-impact aerobic exercises are generally recommended for individuals with PEPCK Deficiency. These activities provide cardiovascular benefits without putting excessive strain on the muscles. Some suitable options include:

• Walking: A gentle and accessible form of exercise that can be easily modified to suit individual fitness levels.


• Swimming: A low-impact activity that provides a full-body workout without putting stress on the joints.


• Cycling: Whether outdoors or on a stationary bike, cycling is a great way to improve cardiovascular fitness without overexertion.


• Yoga or Pilates: These activities focus on flexibility, strength, and balance, and can be adapted to individual needs and abilities.

It is important to start slowly and gradually increase the duration and intensity of exercise. Monitoring blood sugar levels before, during, and after exercise is essential to ensure they remain within a safe range. Individuals with PEPCK Deficiency should work closely with their healthcare team, including a physician and a registered dietitian, to develop an appropriate exercise plan.

Listening to your body is crucial when exercising with PEPCK Deficiency. If you experience symptoms such as dizziness, weakness, or confusion during or after exercise, it is important to stop and rest. Hydration and consuming small, frequent meals or snacks containing carbohydrates can help maintain blood sugar levels during and after exercise.

In conclusion, individuals with PEPCK Deficiency can engage in exercise, but it should be approached with caution. Low-impact aerobic exercises, such as walking, swimming, cycling, and yoga, are generally recommended. Starting slowly, monitoring blood sugar levels, and working closely with healthcare professionals are essential for safe and effective exercise.