What are the best treatments for Peyronies Disease?

Treatments for Peyronie's Disease

Peyronie's Disease is a condition characterized by the development of fibrous scar tissue inside the penis, causing it to curve during erections. This can lead to pain, difficulty with sexual intercourse, and psychological distress. While there is no known cure for Peyronie's Disease, there are several treatment options available to manage the symptoms and improve quality of life.

1. Medications

Medications are often the first line of treatment for Peyronie's Disease. Oral medications such as pentoxifylline and colchicine have been used to reduce plaque formation and decrease pain. Topical verapamil gel has also shown some benefit in reducing plaque size and improving symptoms. However, the effectiveness of these medications varies from person to person.

2. Injections

Injectable medications can be directly administered into the plaque to help soften the scar tissue and reduce curvature. Collagenase clostridium histolyticum (CCH) is an FDA-approved enzyme injection that breaks down the collagen in the plaque, allowing for straightening of the penis. This treatment is typically performed in a series of injections over several months.

3. Extracorporeal Shockwave Therapy (ESWT)

ESWT is a non-invasive procedure that uses low-intensity shockwaves to break down the plaque and stimulate the body's natural healing response. This therapy has shown promising results in reducing pain, improving curvature, and enhancing sexual function in some individuals with Peyronie's Disease.

4. Penile Traction Therapy

Penile traction devices are designed to apply a gentle stretching force to the penis, aiming to straighten the curvature over time. This therapy is typically used for several hours a day over a period of several months. While the evidence supporting its effectiveness is limited, some individuals have reported improvements in penile curvature and pain.

5. Surgery

Surgery is considered when other treatments have failed or if the curvature is severe and significantly affects sexual function. There are several surgical options available, including:

• Plication: The surgeon removes or folds the excess tissue on the side opposite to the curvature, reducing the bend.


• Grafting: A graft of tissue is used to cover the plaque, allowing for straightening of the penis.


• Penile Implants: In cases of severe erectile dysfunction and Peyronie's Disease, penile implants can be considered to restore sexual function and correct curvature simultaneously.

6. Counseling and Psychological Support

Peyronie's Disease can have a significant impact on a person's self-esteem, body image, and sexual relationships. Seeking counseling or joining support groups can provide emotional support and help individuals cope with the psychological aspects of the condition.

It is important to note that the choice of treatment depends on the individual's specific symptoms, disease progression, and personal preferences. Consulting with a healthcare professional who specializes in Peyronie's Disease is crucial to determine the most suitable treatment plan.