Can people with Adult Polyglucosan Body Disease (APBD) work? What kind of work can they perform?

Adult Polyglucosan Body Disease (APBD) is a rare genetic disorder that affects the nervous system. It is characterized by the accumulation of abnormal glycogen deposits in various tissues, including the brain and peripheral nerves. This can lead to a range of symptoms, including progressive muscle weakness, difficulty walking, bladder and bowel dysfunction, and cognitive impairment.

Given the progressive nature of APBD and its impact on physical and cognitive abilities, individuals with this condition may face challenges in the workplace. However, it is important to note that the ability to work can vary greatly depending on the severity of the disease and the specific symptoms experienced by each individual.

For individuals with milder forms of APBD, who may experience minimal physical limitations and cognitive impairment, it may be possible to continue working in their current occupation or make adaptations to their work environment. This could involve modifications such as adjusting work hours, using assistive devices, or making changes to the physical workspace to accommodate any mobility limitations.

For individuals with more severe symptoms, including significant muscle weakness and cognitive impairment, maintaining employment may be more challenging. In such cases, it may be necessary to explore alternative work options that are better suited to their abilities and limitations.

Some potential work options for individuals with APBD could include:

• Desk-based or sedentary jobs: Individuals who experience significant physical limitations may find work opportunities in fields that involve minimal physical exertion, such as administrative roles, data entry, customer service, or remote work that can be done from home.


• Consulting or freelance work: Some individuals may choose to work as consultants or freelancers, offering their expertise in a specific field on a project basis. This can provide flexibility in terms of work hours and workload.


• Advocacy and support roles: Individuals with APBD may find fulfillment in working for organizations that support individuals with disabilities or rare diseases. This could involve roles in advocacy, education, or providing support services to others facing similar challenges.


• Entrepreneurship: Starting a small business or pursuing self-employment can provide individuals with APBD the flexibility to tailor their work environment and schedule to their specific needs.

It is important for individuals with APBD to work closely with healthcare professionals, occupational therapists, and vocational counselors to assess their abilities, identify potential work options, and determine any necessary accommodations or modifications to support their employment. Additionally, workplace policies and legislation related to disability rights and accommodations can provide legal protections and resources for individuals with APBD.

Ultimately, the ability to work with APBD depends on the individual's specific symptoms, disease progression, and the availability of suitable work options. It is crucial to prioritize self-care and make informed decisions about employment that take into account the individual's health, well-being, and overall quality of life.