There are sadly no target treatment methods for depersonalization-derealization disorder at the moment. Most of the time both DP and DR are experienced as symptoms rather than it’s seperate disorder, and if thats the case, treating the existing disorder will alleviate the DPDR symptoms. Medication such as SSRIs, a low dose of new age antipsychotics and anticonvulsant medications have all been used to treat DPDR, but again that most likely targets the underlying issue, thus lessening the DPDR symptoms. For chronic depersonalization-derealization disorder on it’s own, the prognosis is not ideal, but it’s possible to live normally through therapy and/or acceptance.