What is Graft Versus Host Disease
Graft Versus Host Disease description. Find out what Graft Versus Host Disease is and know more about it.
Graft Versus Host Disease (GVHD) is a medical condition that can occur after a stem cell or bone marrow transplant. It happens when the transplanted cells (graft) recognize the recipient's body (host) as foreign and attack it. GVHD can be acute or chronic, with acute GVHD typically occurring within the first few months after the transplant and chronic GVHD developing later.
Acute GVHD affects the skin, liver, and gastrointestinal tract, causing symptoms such as rash, jaundice, diarrhea, and abdominal pain. Chronic GVHD can affect multiple organs and may lead to long-term complications.
The main cause of GVHD is the mismatch between the donor's immune cells and the recipient's tissues. The donor's immune cells recognize the recipient's cells as foreign and initiate an immune response. GVHD can be prevented or treated with immunosuppressive medications that suppress the donor's immune system.
GVHD is a significant concern in transplantation, as it can affect the success of the procedure and the patient's overall well-being. Close monitoring and appropriate medical management are crucial in minimizing the impact of GVHD on transplant recipients.
