Is it advisable to do exercise when affected by Hyper-IgD Syndrome / Hyperimmunoglobulinemia D With Recurrent Fever (HIDS)? Which activities would you suggest and how intense should they be?

Hyper-IgD Syndrome (HIDS), also known as Hyperimmunoglobulinemia D with Recurrent Fever, is a rare genetic disorder characterized by recurrent episodes of fever, accompanied by various symptoms such as abdominal pain, joint pain, and skin rashes. It is caused by mutations in the mevalonate kinase (MVK) gene, leading to the overproduction of a protein called mevalonate kinase.

When it comes to exercise and physical activity for individuals affected by HIDS, it is important to consider the individual's specific symptoms, overall health, and the severity of their condition. It is always recommended to consult with a healthcare professional or a specialist familiar with the condition before starting any exercise regimen.

Regular exercise can have numerous benefits for individuals with HIDS. It can help improve overall physical fitness, strengthen muscles and joints, enhance cardiovascular health, and boost mood and mental well-being. However, it is crucial to choose activities that are safe and appropriate for the individual's condition.

Low-impact exercises are generally recommended for individuals with HIDS, as they are less likely to put excessive strain on the joints and muscles. These can include activities such as:

• Walking: A low-impact exercise that can be easily modified to suit individual fitness levels. It helps improve cardiovascular health and can be done at a pace that is comfortable for the individual.


• Swimming: This is an excellent option as it provides a full-body workout without putting stress on the joints. It helps improve cardiovascular fitness, muscle strength, and flexibility.


• Cycling: Whether on a stationary bike or outdoors, cycling is a low-impact exercise that can be adjusted to the individual's fitness level. It helps strengthen leg muscles and improve cardiovascular health.


• Yoga: Yoga focuses on gentle stretching, flexibility, and relaxation. It can help improve joint mobility, reduce muscle tension, and promote overall well-being.

It is important to start with low to moderate intensity exercises and gradually increase the intensity and duration as tolerated. Listening to the body and avoiding overexertion is crucial, as excessive physical stress can potentially trigger fever episodes in individuals with HIDS.

Warm-up exercises before engaging in any physical activity are essential to prepare the body for exercise and reduce the risk of injury. Similarly, cooling down exercises after the activity can help prevent muscle soreness and promote recovery.

Individuals with HIDS should also be mindful of their hydration during exercise, as fever episodes can lead to increased fluid loss. Drinking plenty of water before, during, and after exercise is important to maintain proper hydration.

In summary, exercise can be beneficial for individuals with HIDS, but it is crucial to choose activities that are safe and appropriate for their condition. Low-impact exercises such as walking, swimming, cycling, and yoga are generally recommended. Starting with low to moderate intensity and gradually increasing as tolerated is advisable. It is always important to consult with a healthcare professional for personalized guidance and recommendations.